Improved Synthesis of Nefazodone from Phenol     

李爱军周雪琴  刘东志 《天津大学学报(英文版)》2006,12(4):248-251

A route for the synthesis of nefazodone is reported. Nefazodone was obtained with an overall yield of 37. 2% from phenol. The key steps involve the improved synthesis of 5-ethyl-4-(2-phenoxyethyl)-1, 2, 4-triazol-3(2H)-one, a key intermediate in the synthesis of nefazodone. The phenol was etherified with 1, 2-dichloroethane (75%), followed by iodination-amination with Nal and CH_3OH-NH_3(85.7%), acylation with ethyl chloroformate (95.7%) and cyclization with propionyl hy-drazine (83.6%).  相似文献   

酯的绿色合成研究的新进展     

边延江  唐春艳  葛建国  孔洁 《廊坊师范学院学报》2004,20(4):7-10,117

综述了近年来国内外酯的绿色合成研究的新进展，并对其发展动态进行了评述。  相似文献   

Cloning and characterization of a glucose 6-phosphate/phosphate translocator from Oryza sativa     

姜华武  佃蔚敏  刘非燕  吴平 《Journal of Zhejiang University. Science. B》2003,(3)

INTRODUCTIONNongreenplastidsofheterotrophictissuesarecarbohydrate importingorganellesand ,inthecaseofamyloplastsofstoragetissues,thesiteofstarchsynthesis.Investigationofwholetissuesfromavarietyofstarchsynthesizingcropplantsindicatedthathexoseunitswereimpo…  相似文献   

低氮低酚冷硬呋喃树脂的研究与应用   总被引：1，自引：0，他引：1  

刘丛  李峰 《河北职业技术学院学报》2002,2(2):33-37

针对铸造生产中使用的冷硬呋喃树脂存在的一些问题 ,研制了一种低氮低酚冷硬呋喃树脂 ,具有良好的使用性能及成本低、少公害等特点  相似文献   

A convenient and stereoselective synthesis of (Z)-allyl selenides via Sm/TMSCI system-promoted coupling of Baylis-Hillman adducts with diselenides     

LIU Yun-kui  XU Dan-qian  XU Zhen-yuan  ZHANG Yong-min 《Journal of Zhejiang University. Science. B》2006,7(5)

  相似文献   

综合文科教育专业课程结构研究——以我校地理教育（历史与社会）专业为例     

白洁 《淄博师专学报》2006,(4):37-42,67

专业课程结构设置是课程建设的基础。我校地理教育（历史与社会）专业课程的设置结构，在充分借鉴国内师范院校综合文科教育专业课程结构研究经验的基础上，按照均衡性、综合性、选择性和人文性的组织原则，设置了通识教育课程、教育专业课程、学科专业课程和教育实践课程等四大模块。这就形成了知识与技能兼顾、理论与实践并重的课程设置特色。  相似文献   

微波化学实验Ⅱ.乙酰苯胺的制备     

张力  白林  李康兰  王永红 《甘肃高师学报》2006,11(5):86-87

采用苯胺与乙酸酐反应,微波辐射下直接回流合成了乙酰苯胺.与传统实验方法相比反应条件温和,易控制,反应过程中无毒害物质产生,反应时间短,产品质量和产率高,重复性好,适宜于实验教学,效果良好.  相似文献   

基于模糊变权法的《动车组结构及原理》教学模式改革评价     

李永华  王剑  宫琦 《教育教学论坛》2020,(7):119-120

文章以《动车组结构及原理》课程为例,结合模糊层次分析法和变权综合法提出一种基于模糊变权法的教学模式改革评价方法。该方法有效降低各评价因素权重的主观性,更好地反映改革的整体评价结果,对同类课程的教学模式改革具有一定的借鉴意义。  相似文献   

Mobile APP for motivation to learning: an engineering case     

Min Jou  Yen-Ting Lin  Hsieh-Chih Tsai 《Interactive Learning Environments》2016,24(8):2048-2057

Synthesis of Materials is regarded as an important core subject in engineering education. However, many concepts and knowledge in the material synthesis can be rather abstract and difficult to understand by the student learners. Experiments are limited in scope due to lack of equipment, control of toxic materials, and risks of chemical reactions, which often restricts student imagination and student involvement in practical training. These reasons often led to poor learning attitude and learning performance among the students. Rapid developments in Cloud technology and mobile devices have provided new opportunities for developing novel learning tools for material synthesis. This study aims to introduce interest factors as a strategy for promoting learning interest and practical skills among the students. Chemical symbols, experimental themes, texts, and interactive elements were utilized to develop a theme-based Mobile Learning APP for teaching the practical techniques of material synthesis. The Mobile Learning APP was then integrated into a problem-based learning activity. A quasi-experimental design was used to investigate the resulting learning effectiveness from using the developed Mobile Learning APP. Results show that the Mobile Learning APP provided a significant positive effect on learning performance and that most students showed favorable attitudes toward the usage of the mobile learning system.  相似文献   

F^-在有机合成反应中的应用     

周勇 《平原大学学报》2001,18(2):72-74

综述了氟离子作为电子供给体和非亲核性的催化剂在烷基化反应、羟醛缩合反应、Michael加成、Knoevenagel缩合反应、Wittig反应和Wittig-Horner反应、重氮化反应等有机反应中应用，并对其催化机理进行了探讨。  相似文献